Simplicioceras centrale was a rounded chambered cephalopod that lived in the Eocene seas represented by the London Clay. The chambers inside its coiled shell controlled buoyancy, while the animal occupied the outermost body chamber and could move through the water by jet propulsion.

Its feeding behaviour is not directly preserved. Like other nautiloids it was probably a predator and scavenger, taking small animal prey and carrion. Its smooth, rounded shell shows that London Clay nautiloids were not all built alike: this form was more compact and evenly rounded than the sharper-profiled Deltoidonautilus.