Isurolamna inflata was a lamniform mackerel-shark-type predator known from robust teeth. Its dentition suggests an active animal capable of seizing and cutting fishes and other sizeable marine prey in open or shelf waters.

The broad-based teeth imply a stronger cutting component than the very slender piercing dentitions of many sand-tiger-type sharks. This points to a predator able to handle relatively substantial prey, although neither its exact body size nor its hunting behaviour can be established from teeth alone.

The species is known almost entirely from dental material, and the limits of the name have not been revised as thoroughly as those of some other Eocene sharks. Its broad ecological interpretation as an active lamniform predator is therefore more secure than any detailed reconstruction of its body form or biology.